Found inside – Page 1... thereby terminating the cellular DNA chain Therapeutic outcome: Decreased symptoms of HIV USES: In combination with other antiretroviral agents for HIV-1 infection (not to be used with lamivudine or tenofovir) CONTRAINDICATIONS: ... Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, What You Should Know About the Delta Variant, Combo COVID, Flu Shot Appears Safe & Effective, Harnessing the Power of AI to Speed Drug Development, Health News and Information, Delivered to Your Inbox, Why Heart Failure Is Not Part of the Aging Process, List emtricitabine-tenofovir DISOP side effects by likelihood and severity. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. DESCRIPTION. endstream
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stream CONTRAINDICATIONS In clinical trials, the most common side effects reported with tenofovir alafenamide were headache, nausea, and fatigue. Found insideOral Tablet: (emtricitabine/tenofovir) 100 mg/150 mg, 133 mg/200 mg, 167 mg/250 mg, 200 mg/300 mg Common FDA Label ... tenofovir, renal 70-80% with a half-life of 17 h Contraindications Do not use for preexposure prophylaxis in patients ... None. The following conditions are contraindicated with this drug. The pharmacologic action is exerted through blocking the enzyme reverse transcriptase. Found inside – Page 188PATIENT TEACHING • Instruct patient to take tenofovir with a CONTRAINDICATIONS meal to enhance bioavailability . Contraindicated in patients hypersensitive • If patient takes tenofovir and didanosine to any component of the drug . 300mg. Do not coadminister SYMTUZA ® and the following drugs due to the potential for serious and/or life-threatening events or loss of therapeutic effect: alfuzosin, carbamazepine, colchicine (in patients with renal and/or hepatic impairment), dronedarone, elbasvir/grazoprevir, ergot derivatives (such as: dihydroergotamine, ergotamine, methylergonovine), ivabradine, lomitapide . Emtricitabine and tenofovir can be used to treat HBV, and discontinuation of these medicines can cause rebound hepatitis. Found inside – Page 1167PRECAUTIONS Contraindications: Hypersensitivity to tenofovir. Cautions: Hepatic/renal impairment, pts at risk for hepatic disease (e.g., obesity); concurrent nephrotoxic medications, pts with low body weight, risk factors or prior ... 4 CONTRAINDICATIONS 4 CONTRAINDICATIONS None. 4 CONTRAINDICATIONS All rights reserved. For Healthcare Professionals. Found inside – Page 1276tenofovir 1276 alafenamide INTERACTIONS Increased bleeding with aspirin, indo- methacin, phenylbutazone, ... not indicated for HIV-1 infection CONTRAINDICATIONS: Hypersensitivity to product T tenofovir 1278 disoproxil fumarate q72–96h; ... In settings where HIV is prevalent in heterosexual populations, pregnancy and postpartum breastfeeding periods can be associated with substantial HIV acquisition risk. Found inside – Page 55Co-administration with cobicistat or the NNRTIs efavirenz/etravirine/nevirpine is contraindicated. ... (TAF) The active moiety tenofovir (TFV) is poorly bioavailable and thus administered as salts that cross the gut and are ... Prescribing information: Consult the full Prescribing Information for DESCOVY ® for more information, warnings, and potentially significant drug interactions, including clinical comments . minimum 1 year, continue for at least 6 months after HBeAg seroconversion; IFNa non-responders / contraindications to IFNa -> TDF/ETV. %PDF-1.7
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CONTRAINDICATIONS APO-EMTRICITABINE-TENOFOVIR is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the product. Found inside – Page 504Use with sildenafil for pulmonary arterial hypertension is contraindicated. ... Use together is contraindicated. ... HBV and HIV-1 and have discontinued emtricitabine (Emtriva) or tenofovir (Viread), which are components of this drug. Found inside – Page 311... adults/virologically suppressed adults on an antiretroviral regimen ≥6 mo and who are without resistance-associ- ated substitutions to darunavir or tenofovir CONTRAINDICATIONS: Hypersensitivity codeine (Rx) (koe′deen) Func. class. endstream
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stream Things to remember when you fill your prescription. Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing emtricitabine and/or tenofovir disoproxil . For a complete listing, see the DOSAGE FORMS, COMPOSITION AND PACKAGING section of the Product Monograph. x�]��n�@E����Dʬ wuU"E����D! What conditions does tenofovir alafenamide oral treat? 4 CONTRAINDICATIONS . Found inside – Page 431Contraindicated in patients who are positive for HLA‐B*5701 Cobicistat: CYp3A inhibitor, numerous drug–drug interactions All medications that are joined by a forward slash (e.g. tenofovir/emtricitabine) are available in co‐formulated ... Tenofovir is an antiviral medicine that is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). The combination of bictegravir, emtricitabine, and tenofovir works by decreasing the amount of HIV in the body. It also inhibits hepatitis B virus polymerase, resulting in inhibition of viral replication. A typical initial HIV regimen includes 3 HIV medications from a minimum of 2 drug classes. Fixed-dose combination bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir-containing regimens for initial treatment of HIV-1 infection: week 144 results from two randomised, double-blind, multicentre, phase 3, non-inferiority trials. TEMIXYS is contraindicated in patients with a previous hypersensitivity reaction to any of the components This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. Found inside – Page 106When administered with tenofovir, H2-receptor antagonists, or proton pump inhibitors, give 300 mg with ritonavir 100 ... when administered with either an H2-receptor antagonist or tenofovir Contraindications ○ Hypersensitivity to drug ... Contraindications: Efavirenz, emtricitabine and tenofovir disoproxil fumarate tablets are contraindicated in patients with previously demonstrated clinically significant hypersensitivity (e.g., Stevens-Johnson syndrome, erythema multiforme, or toxic skin eruptions) to efavirenz, a component of efavirenz, emtricitabine and tenofovir disoproxil . [57194] Patients with hepatitis B and HIV coinfection . Truvada® (tenofovir disoproxil fumarate-emtricitabine 300 mg/200 mg) 1 tab PO daily, #30, 2 refills for a total 90-day supply PrEP INDICATIONS CONTRAINDICATIONS CAUTION Prescribing Pre-Exposure Prophylaxis (PrEP) for A Guide for Medical Providers Emtricitabine and tenofovir (Truvada) is also used along with practicing safer sex (e.g., condom use) to reduce the risk of HIV infection) in high-risk adults and teenagers who weigh at least 77 pounds (35 kg). However, in exceptional circumstances Tenofovir disoproxil Mylan 245 mg film-coated tablets can be administered following disintegration of the tablet in at least 100 ml of water, orange juice or grape juice. Should I avoid certain foods while taking emtricitabine-tenofovir DISOP? Found inside – Page 428Adjust dosage or stop drug if peripheral neuropathy occurs . tenofovir CONTRAINDICATIONS AND CAUTIONS Contraindicated in patients hypersensitive to the drug or its components and in patients with a creatinine clearance less than 60 ml ... Found inside – Page 496TABLE Contraindications to Pegylated Interferon 33-4 Therapy Decompensated cirrhosis Severe psychiatric disease ... add resistance tenofovir (or alternatively emtricitabine-tenofovir) Telbivudine resistance Tenofovir Continue with ... Pharmacokinetics: Found inside – Page 529See tenofovir alafenamide for bone disease, 467–68 for cervical cancer, 256, 257t for CKD, 460 for cognitive ... 290, 291t contraindications to, 302 darunavir, cobicistat, emtricitabine, and tenofovir AF (Symtuza), 118, 177–78, ... emtricitabine, and 300 mg of tenofovir DF (equivalent to 245 mg of tenofovir disoproxil). (7.2) Coadministration decreases atazanavir concentrations. Coadministration of VIREAD with certain HIV-1 protease inhibitors endstream
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stream Canadian labeling: Additional contraindications . Tenofovir Disoproxil Fumarate is available as tablets. . (PrEP) with daily tenofovir disoproxil fumarate-emtricitabine is recommended as one HIV prevention option for men who have sex with men (MSM), injection drug users (IDU), and heterosexual men Oe�I��ubMg��.D�(���
\AJ��3/SN+�k��H�n�����������Y`�`�=����m�D ���u/���i��9n�P�0�;��7��dx Although this treatment is not curative, it can provide longer lives for patients and reduce HIV transmission. Drug Interactions: Tenofovir slightly inhibits CYP1A2. Found inside – Page 133Half-life: (bictegravir): 17 hrs; (emtricitabine): 10 hrs; (tenofovir): 0.5 hrs. USES Indicated as complete ... PRECAUTIONS Contraindications: Hypersensitivity to bictegravir/emtricitabine/tenofovir. Concomitant use of dofetilide, ... The yellow to yellowishbrown, capsule-shaped, - film-coated tablet is debossed with "8121" on one side and "JG" on the other side. tenofovir disoproxil fumarate. DESCRIPTION. dosing with tenofovir alafenamide cannot be excluded (see section 5.3). Tenofovir is efficiently removed by hemodialysis with an extraction coefficient of approximately 54%. emtricitabine - tenofovir alafenamide (Descovy®) Emtricitabine - tenofovir alafenamide (Descovy®) may be considered medically necessary for the following indications: • Treatment of HIV-1 in people who have a contraindication to emtricitabine - tenofovir disoproxil fumarate. Precautions and Contraindications. endstream
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stream LAM and LdT not preferred due to high rate of drug resistance . <2 years: Safety and efficacy not established. Following a single 300 mg dose of TDF, a 4-hour hemodialysis session removed approximately 10% of the administered tenofovir dose. This Pharmacy Coverage Guideline must be read in its entirety to determine coverage eligibility, if any. Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing emtricitabine (FTC) and/or tenofovir disoproxil fumarate (TDF), and may . Tenofovir is not a cure for HIV or AIDS. Tenofovir alafenamide, an HIV NRTI, is converted in vivo to tenofovir, an acyclic nucleoside phosphonate analog of adenosine 5'-monophosphate. Found inside – Page 311311 codeine TREATMENT OF OVERDOSE: Lavage; provide an airway; do not induce vomiting CONTRAINDICATIONS: ... vemurafenib 960 mg bid × 28 days; repeat cycle q28days until disease proemtricitabine/tenofovir Symtuza Func. class. Contraindications. . H�����4&�W�\H�l�'1$] 28-36kg: Emtricitabine 167 mg/tenofovir 250 mg PO once daily. © 2005 - 2021 WebMD LLC. Indicated for treatment of HIV infection in combination with other antiretroviral agents in children aged 2 years or older. Find out what health conditions may be a health risk when taken with emtricitabine-tenofovir . What should I know regarding pregnancy, nursing and administering emtricitabine-tenofovir DISOP to children or the elderly? 5.8 Early Virologic Failure This reduction of transmission has become a popular use of antiretroviral therapy for HIV-positive individuals and are with an HIV-negative partner. Tenofovir alafenamide fumarate has an empirical formula of C 21 H 29 O 5 N 6 P∙½(C 4 H 4 O 4) and a formula weight of 534.5 and has the following structural formula: Tenofovir alafenamide fumarate is a white to off-white or tan powder with a solubility of 4.7 mg per mL in water at 20 °C. ` d3��2�-f���01�:( � �Ml�yT��:�� �z} Tenofovir disoproxil Mylan tablets should be taken once daily, orally with food. Check with . Found inside – Page 226TIME/ACTION PROFILE (plasma concentrations) ROUTE ONSET PEAK DURATION bictegravir PO unknown 2–4 hr 24 hr emtricitabine unknown 1.5–2 hr 24 hr PO tenofovir PO unknown 0.5–2 hr 24 hr Contraindications/Precautions Contraindicated in: ... Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. It is generally recommended for use with other antiretrovirals. ≥2 years and weigh (≥10 kg): 8 mg/kg PO qDay; not to exceed 300 mg/day. 4.3 Contraindications. CONTRAINDICATIONS. q Doctors historically have not treated this group because there appeared to be no sign of liver damage. Absorption. PMPApp works as a chain terminator if incorporated into the DNA chain and is a competitive inhibitor of natural deoxyadenosine 5′-triphosphate. Found inside – Page 226TIME/ACTION PROFILE (plasma concentrations) ROUTE ONSET PEAK DURATION bictegravir PO unknown 2–4 hr 24 hr emtricitabine unknown 1.5–2 hr 24 hr PO tenofovir PO unknown 0.5–2 hr 24 hr Contraindications/Precautions Contraindicated in: ... Found inside – Page 568... Prostin E2), 359t actions, 354 adverse reactions, 355–356 contraindications, precautions, and interactions of, ... 400, 409t Efavirenz/Emtricitabine/Tenofovir disoproxil fumarate (Atripla), 409t Efficacy, 497 Ejection fraction, ... When coadministered with VIREAD, use atazanavir given with ritonavir. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? Tenofovir disoproxil fumarate is a nucleotide analog reverse transcriptase inhibitor. APO-EMTRICITABINE-TENOFOVIR is contraindicated for use as PrEP in individuals The tablets are white, oblong shape, film-coated tablets debossed with "C 0" on one side and plain on the other side. (4) rifampin. In addition, animal studies have also shown the excretion of tenofovir in breast milk. An international study found the antiviral combination of tenofovir and emtricitabine ( Truvada) was most effective in treating younger adult hepatitis B patients with high viral load and normal ALT levels. Description: Tenofovir disoproxil fumarate (TDF) is a prodrug of tenofovir. SYMTUZA™ (darunavir, cobicistat, emtricitabine, tenofovir alafenamide) oral Page 1 of 8 . To date, the safety and effectiveness of tenofovir in pediatric patients have not been established; studies in this patient population are under way. Tenofovir disoproxil fumarate is a recommended component of a regimen when acute HIV infection is detected in breastfeeding females. x���K�@�}0��.+Hg�)���H�^�ڈXd�����Z�����^�s�'�"�1c? Found inside – Page 848Contraindications—hypersensitivity to drug or class, CrCl <60 mL/min, lactic acidosis • Caution—alcoholism, ... A single dose of tenofovir plus emtricitabine at delivery reduced by half the rate of resistance to NNRTIs 6w after delivery ... Contraindications. All patients should undergo hepatitis B virus (HBV) screening and HIV antibody testing prior to the initiation of tenofovir to ensure appropriate treatment. ���� JFIF � � �� ZExif MM * J Q Q �Q � �� ���� C [28193] Additionally, individuals without HIV who are receiving tenofovir for pre-exposure prophylaxis of HIV should also undergo HBV screening every 6 to 12 months while on therapy. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases that include mitochondrial DNA polymerase γ and there is no evidence of toxicity to mitochondria cell culture. DELSTRIGO is a fixed-dose combination, film-coated tablet, containing doravirine, lamivudine, and TDF for oral administration. Orkin C, DeJesus E, Sax PE, et al. However, this is not expected to lead to any clinically significant drug interactions. The tablets are white circular film coated, convex tablets engraved "TDF" on one side and plain on other side. CONTRAINDICATIONS • HIV-positive • Estimated creatinine clearance (eCrCl) < 60 ml/min • Possible HIV exposure within 72 hours . 4.4 Special warnings and precautions for use . Found inside – Page 1051Patient/Client-Related Instruction Emphasize the importance of taking tenofovir as directed even if the patient is asymptomatic, ... Contraindicated in: Hypersensitivity; Lactation: HIV-infected women should not breast-feed ... General. Found inside – Page 42... Major Drug Interactions Concomitant administration with emtricitabine should • be avoided because they are chemically related Contraindications Concomitant administration with emtricitabine • Key Points Lamivudine or emtricitabine ... When treating chronic hepatitis B with tenofovir, monitor liver function tests every 3 months and viral markers for hepatitis B every 3-6 months during treatment (continue monitoring for at least 1 year after discontinuation—recurrent hepatitis may occur on discontinuation). Found inside – Page 1164Screen for contraindications (e.g., history of CVA, bleeding of any kind, uncontrolled hypertension). ... FIXED-COMBINATION(S) Atripla: tenofovir/efavirenz/emtricitabine (antiretroviral agents): 300 mg/600 mg/200 mg. WebMD does not provide medical advice, diagnosis or treatment. Found inside – Page 396396 doravirine/lamivudine/tenofovir USES: Human immunodeficiency virus (HIV) infection in antiretroviral-naive adults ... lamivudine 300 mg; tenofovir disoproxil fumarate 300 mg) daily, then 12 hr later, give CONTRAINDICATIONS: Hyperan ... Found inside – Page 93Contraindications: Do not use emtricitabine if allergic to any of its components. ... 11.45 HIV Antivirals—Protease Inhibitors transcriptase inhibitors (NRTIs) such as emtricitabine and tenofovir work at the reverse transcription step, ... Found inside – Page 19Inform patient that efavirenz, emtricitabine, and tenofovir therapy doesn't cure HIV infection and doesn't reduce the risk of transmitting HIV ... Contraindications Concurrent or recent therapy with a nephrotoxic drug; hypersensitivity. After oral administration of tenofovir disoproxil to patients with HIV infection, tenofovir disoproxil is quickly absorbed and metabolized to tenofovir 16.. Administration of tenofovir disoproxil 300 mg tablets after a high-fat meal increases the oral bioavailability of this drug, as demonstrated by an increase in tenofovir AUC0-∞ of about 40% as well as an increase in Cmax of . Tenofovir disoproxil fumarate (tenofovir DF) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 2 years of age and older who weigh at least 22 lb (10 kg). Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Contraindications and drug interactions 1 Contraindication. 1 Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal . These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. Contraindications (conditions in a recipient that increases the risk for a serious adverse reaction) to vaccination are conditions under which vaccines should not be administered. If you are HBeAg-, HBV DNA (PCR) >20,000 IU/mL ALT >2 x ULN, then, IFN-a/peg IFN-a, LAM, ADV, ETV, TDF or LdT may be used as initial therapy. As a nucleotide, tenofovir disoproxil fumarate remains in the . Updated contraindications and precautions to vaccination Recommendations apply to both Pfizer-BioNTech and Moderna COVID-19 vaccines Guidance may change as further information becomes available Definition of immediate allergic reaction to vaccine or medication: Any hypersensitivity-related signs or symptoms such as urticaria, >35kg: Emtricitabine 200 mg/tenofovir 300 mg PO once daily. 8. The tablets are purplish pink, capsule shaped, film coated, debossed with "GSI" on one side, and plain faced on the other side. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. endstream
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stream WebMD provides common contraindications for tenofovir alafenamide oral. Following a single 300 mg dose of VIREAD, a four-hour hemodialysis session removed approximately 10% of the administered tenofovir dose. Found inside – Page 132PRECAUTIONS Contraindications: Hypersensitivity to bic- tegravir/emtricitabine/tenofovir. Con- comitant use of dofetilide, rifampin. ... INTERACTIONS DRUG: May significantly increase concentration/effect of dofetilide (contraindicated). 5.1 Lactic Acidosis/Severe Hepatomegaly with Steatosis . WebMD does not provide medical advice, diagnosis or treatment. DESCOVY FOR PREP ® is contraindicated in patients with unknown or positive HIV status; Drug interactions. Cautions. Found inside – Page 579reverse 11.4.7 Tenofovir Alafenamide (TAF) few case reports, it is detailed that tenofovir 11.4.7.1 Mechanism of Action administered concomitantly with didanosine 1. ... In a use cause or 11.4.7.5 Contraindications 1. 17-22kg: Emtricitabine 100 mg/tenofovir 150 mg PO once daily. Tenofovir Contraindications in Pregnancy Although it's contraindicated, various research shows that there are no adverse reactions (that may demand safety-related precautions) for preventing the use of tenofovir DF during pregnancy or when breastfeeding [5] . Tenofovir is administered as the prodrug tenofovir disoproxil fumarate (9- [ (R)-2- (phosphonomethoxy)prophy]adenin, or PMPA), a nucleotide that is phosphorylated to PMPApp. 4 CONTRAINDICATIONS Each tablet contains darunavir ethanolate equivalent to 800 mg of darunavir, 150 mg of cobicistat, 200 mg of emtricitabine, and 11.2 mg of tenofovir . 5.2 HBV Infection . It is recommended that renal function is assessed in all patients prior to, or when initiating, therapy . Found inside – Page 336Didanosine Pancreatitis, peripheral neuropathy, higher risk of Contraindication with ribavirin and allopurinol. Avoid with stavudine (significant overlapping toxicities). Emtricitabine Usually well tolerated Potential for exacerbation ... WebMD provides common contraindications for emtricitabine-tenofovir disoproxil fumarate oral. Found inside – Page 1186contraindications (e.g., history of CVA, bleeding of any kind, uncontrolled hypertension). ... FIXED-COMBINATION(S) Atripla: tenofovir/efavirenz/emtricitabine (antiretroviral agents): 300 mg/600 mg/200 mg. Tenofovir is efficiently removed by hemodialysis with an extraction coefficient of approximately 54%. Found inside – Page 1553CONTRAINDICATIONS Hypersensitivity to tenofovir, T concurrent use of tenofovir- containing combinations. INTERACTIONS Drug Acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir: May increase the blood concentrations of ... There are no contraindications listed in the manufacturer's US labeling. • Pre-exposure prophylaxis (PrEP) of HIV-1 in studied populations Tenofovir DF is converted in vivo to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5'-monophosphate. Selected from data included with permission and copyrighted by First Databank, Inc. 1 tablet of each once daily e. £343.37 b Bone Effects of Tenofovir DF 5.6 Fat Redistribution . 5.7 Immune Reconstitution Syndrome . This survey is being conducted by the WebMD marketing sciences department. (3) -----CONTRAINDICATIONS----- BIKTARVY is contraindicated to be co-administered with: dofetilide. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Tenofovir, Lamivudine, and Dolutegravir (TLD) Transition General Information for Clients, Clinicians, Counselors, and other Service Providers AUGUST 2019. Emtricitabine, Rilpivirine, And Tenofovir Alafenamide Found inside – Page 48Two antiretroviral medications are approved: • Emtricitabine and tenofovir disoproxil fumarate ... through receptive vaginal sex Actions • Interferes with HIV viral replication Contraindications and Precautions • Severe liver problems ... If combined in adults with CrCL greater than 60 mL/min, decrease didanosine to 250 mg daily if 60 kg or more or to 200 mg if less than 60 kg.
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