Psoriatic arthritis (PsA) is a complex inflammatory musculoskeletal and skin disease. Dietary modification include: Rheumatoid arthritis is a chronic disorder that has no cure. 2002;2:CD003687. All individuals have multiple exacerbations and remissions. 2021;73(7):924-939. methotrexate, leflunomide, prednisolone, biological DMARDs (bDMARDs): e.g. Pubmed. Introduction: Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease and is associated with an excess risk of cardiovascular disease. The treatment of rheumatoid arthritis (RA) is directed toward the control of synovitis and the prevention of joint injury. Found inside – Page 171Non-drug treatment (excluding surgery) in rheumatoid arthritis: clinical practice guidelines. ... Quality appraisal of clinical practice guidelines on the use of physiotherapy in rheumatoid arthritis: a systematic review. At the 2015 ACR/ARHP Annual Meeting, the ACR unveiled the 2015 Guideline for the Treatment of Rheumatoid Arthritis. General Rheumatology. Arthritis Care & Research. [Guideline] Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, et al. Clipboard, Search History, and several other advanced features are temporarily unavailable. All current UK clinical guidelines for the management of RA recommend the use of physiotherapy (PT) and occupational therapy (OT) as an adjunct to drug treatment. This guideline covers diagnosing and managing rheumatoid arthritis. 6. In most cases Physiopedia articles are a secondary source and so should not be used as references. 267 0 obj <>/Filter/FlateDecode/ID[<3FDDDC966664A5246908F205A9111A70>]/Index[255 22]/Info 254 0 R/Length 79/Prev 1021407/Root 256 0 R/Size 277/Type/XRef/W[1 3 1]>>stream The use of social media by arthritis health professionals to disseminate a self-management program to patients: A feasibility study. The most comprehensive pathology text designed specifically for physical therapists, this book offers guidelines, precautions, and contraindications for physical therapy interventions with clients who have musculoskeletal or neuromuscular ... Treatment of rheumatoid arthritis is aimed at improving the symptoms and slowing disease progression. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis This clinical practice guideline is intended to serve as a tool to support clinician and patient decision-making. Several new developments have led to changes in the EULAR recommendations to treat rheumatoid arthritis. Improvement in disease management knowledge, Improvement in activities of daily living, Improvement in Joint stiffness (~ Range of motion), Physical exercise helps to increase the physical capacity of the patient, Exercise improves general muscular endurance and strength without detrimental effects on disease activity or pain in RA. Accessibility Ankylosing spondylitis (AS) is a condition that mainly affects the spine. Clinical Practice Guideline for Physical Therapist Management of People With Rheumatoid Arthritis. Found inside – Page 260Clinical practice guideline for the physiotherapy of patients with whiplash - associated disorders . Spine , 27 , 412-422 . Scottish Intercollegiate Guidelines Network ( 2002 ) . Managementt of early rheumatoid arthritis . non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), conventional synthetic DMARDs (csDMARDs): e.g. [13], Transcutaneous electrical nerve stimulation (TENS) is used to relieve pain. This site needs JavaScript to work properly. Criterion validation of two submaximal aerobic fitness tests, the self-monitoring Fox-walk test and the Åstrand cycle test in people with rheumatoid arthritis. The implementation of the guideline in clinical practice needs further evaluation. The American College of Rheumatology (ACR) has released new guidelines on the treatment of rheumatoid arthritis, including 44 treatment recommendations, 7 of which are considered strongly recommended.. Little C, Parsons T. Herbal therapy for treating rheumatoid arthritis. 2011 Jul-Sep;36(3):268-81. Found insideJuvenile rheumatoid arthritis: benefits from massage therapy. ... title=World+Health+Guidelines+on+basic+training+and+safety+in+Chiropractic&publication_year=2005&. 75. ... The Chartered Society of Physiotherapy (CSP). (2018, March 14). Based on the ICF core sets for RA a list of health problems relevant for the physiotherapist was made and completed with red flags and points of attention. (Level 1B). Preference is given to an active policy, especially where the physiotherapist has a supporting role. Physiotherapy and rehabilitation applications significantly augment medical therapy by improving the management of RA and reducing handicaps in daily living for patients with RA. (Level 1B), Brodin N, Eurenius E, Jensen I, Nisell R, Opava CH, PARA study group. All current UK clinical guidelines for the management of RA recommend the use of physiotherapy (PT) and occupational therapy (OT) as an adjunct to drug treatment. 3. This KNGF guideline refers exclusively to RA, and not to other rheu- Found insideBSR and BHPR rheumatoid arthritis guidelines on the safety on anti-TNF therapies. London: BSR, 2010. ... 3.4), with input from specialist consultant, specialist nurse, paediatric physiotherapist ... To improve the quality of the physiotherapy management in patients with rheumatoid arthritis (RA) a Dutch practice guideline, based on current scientific evidence and best practice, was developed. X-ray of both hands and feet are usually obtained for the presence of erosions, the pathognomonic feature of rheumatoid arthritis (plain radiograph does not show early changes of the disease). Before beginning an exercise program perform a global evaluation of the situation: joint-inflammation local or systemic, state of the disease, age of the patient and grade of collaboration. cess of physical therapy for patients with rheumatoid arthritis (RA). OA of the knee and hip is a growing health concern and is the most common forms of arthritis 1-3. This supplement reviews key changes to the latest American College of Rheumatology (ACR) guidelines for rheumatoid arthritis (RA) and how they may be implemented to meet the unique needs of veterans. Rheumatoid Arthritis Information & Guidelines. Tendon repair. Magnetic resonance imaging (MRI) and ultrasound of joints detect erosions earlier than an x-ray. DAS-Crp (disease activity score): tender joint count, swollen joint count, patient global assessment, and c reactive protein in mg/dl. The pharmacist should educate the patient on types of drugs used to treat rheumatoid arthritis and their potential side effects. 2011 Oct;50(10):1879-88. doi: 10.1093/rheumatology/ker195. Pain and disease can range from very mild to very severe 3. Introduction. Patients with rheumatoid arthritis should have access to a multidisciplinary team, and may benefit from physiotherapy to encourage exercise, enhance flexibility of joints and strengthen muscles. Includes; ROM-exercises; aerobic exercise: stabilisation/coordination exercises. Hurkmans EJ, Li L, Verhoef J, Vliet Vlieland TP. In 80-90% of the patients with rheumatoid arthritis the cervical spine is involved, which can lead to instability, caused by the ligamentous laxity (between the first and second cervical vertebrae most commonly) This instability can lead to pain and neurological symptoms,eg headache and tingling in the fingers. 1 INTRODUCTION. Cardiovascular morbidity and mortality in rheumatoid arthritis. The text focuses on applying evidence-based understanding of these conditions to clinical context. Arthritis Care and Res. Treatment of Rheumatoid Arthritis x 1. With respect to treatment a systematic literature search was performed using various databases, and the evidence was graded (1-4). 5: RA Disease State Background and Clinical Burden. Worse outcomes are usually seen in patients with a high titer of autoantibodies, HLA-DRB1 genotypes, age younger than 30, multiple joint involvement, female gender, and extra-articular involvement. Physiotherapy in hip and knee osteoarthritis: development of a practice guideline concerning initial assessment, treatment and evaluation. [Guideline] Aletaha D, Neogi T, Silman AJ, et al. The three most important complaints are the pain, morning stiffness and fatigue. Increases risk: Female sex; occupational dust (silica); air pollution; high sodium red and iron consumption; low vitamin D intake and levels; Deceased risk: fish and omega 3 fatty acid consumption; moderate alcohol intake; healthy diet; oral contraceptive/HRT; statin use. Eventually, the swelling caused by RA can lead to joint deformities and bone erosion. Found inside – Page 453Physiotherapy 92 (2), 95–102. ... Physical Therapy in Sport 7, 74–80. ... Ottawa panel evidence-based clinical practice guidelines for electrotherapy and thermotherapy interventions in the management of rheumatoid arthritis in adults. Aletaha D, Neogi T, Silman AJ, et al. It aims to improve quality of life by ensuring that people with rheumatoid arthritis have the right treatment to slow the progression of their condition and control their symptoms. (Level1), Jong Z de, Munneke M, Zwinderman AH, Kroon HM, Jansen A, Ronday KH, et al. Found inside – Page 165Rheumatoid arthritis. In: eTG complete [Internet]. Therapeutic Guidelines Limited, Melbourne. Therapeutic Guidelines Limited, 2010e. Fish oil (omega-3 long chain polyunsaturated 165 CHAPTER 5 ORTHOPAEDiC AnD muSCulOSkElETAl SySTEmS. Am J Med. Ottawa Panel. h�b```f``���+�@��Y8� ��* Vander Cruyssen, B., et al., DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment. Besides the joint disease, the individuals can suffer from many extra joint related problems which significantly alters the. Results: The guideline addresses treatment with disease-modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs, biologic DMARDs, and targeted synthetic DMARDs, use of glucocorticoids, and use of DMARDs in certain high-risk populations (i.e., those with liver disease, heart failure, lymphoproliferative disorders, previous serious infections, and … 64. Arthritis afflicts approximately 43 million Americans or approximately 16.6% of the US population. 5th edition. That is usually the journal article where the information was first stated. On average, the chronic RA patient has two or more comorbid conditions. Activation and accumulation of CD4 T cells in the synovium start a cascade of inflammatory responses which result in: The inflammatory response leads to Pannus formation. Original Editors - Florence Brachotte Amanda Fetz & Katie Robertson from Bellarmine University's Pathophysiology of Complex Patient Problems project, Top Contributors - Amanda Fetz, Riley Sturzebecher, Lucinda hampton, Kim Jackson, Amanda Ager, Admin, Elaine Lonnemann, Wendy Walker, Katie Robertson, WikiSysop, Simisola Ajeyalemi, Shaimaa Eldib and Amrita Patro   Amanda Fetz,Riley Sturzebecher,Elaine Lonnemann,Rachael Lowe. 2007. Aerobic capacity over 16 years in patients with rheumatoid arthritis: Relationship to disease activity and risk factors for cardiovascular disease. Tak. Found inside – Page 637... for Health and Clinical Excellence, 11 National Osteoporosis Society, 183 national standards and guidelines applied locally, ... in rheumatoid arthritis, 506 neurological tests (incl. neural tests) cervical spine, 41–3 hip joint, ... Ottawa Panel Evidence-Based Clinical Practice Guidelines for Therapeutic Exercises in the Management of Rheumatoid Arthritis in Adults. 0 U.S. Food and Drug Administration. The 2021 Treatment Guidelines for Rheumatoid Arthritis. Rheumatoid arthritis (RA) is a common immune-mediated inflammatory arthritis, affecting approximately 5 per 1000 adults worldwide [].RA has a significant negative impact on daily activities, including work and household tasks, and is associated with high burden and impaired quality of life (QoL) [1, 2].During recent decades, the target of RA treatment has changed from … Commonly joint involvement occurs insidiously over a period of months, however, in some cases, joint involvement may occur over weeks or overnight. A first draft of the guideline was reviewed by 10 experts from different professional backgrounds resulting in the final guideline. The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered (or self-administered) to patients, with the aim to cure them, vaccinate them, or alleviate the symptoms. Arthritis Res Ther, 2005. Surgery to remove the inflamed lining of the joint (synovium) can help reduce pain and improve the joint's flexibility. 2001. 22 January 2018 - 4:44PM. The Cochrane Database of Systematic Reviews. Acutely, inflamed joints should be rested to prevent exacerbation of symptoms. Nordgren B, Fridén C, Jansson E, Österlund T, Grooten WJ, Opava CH, Rickenlund A. BMC Musculoskelet Disord. Found inside – Page 156American College of Rheumatology Guidelines for the management of rheumatoid arthritis. ... Chamberlain MA, Care G. and Harfield B Physiotherapy and osteoarthrosis of the knees: a controlled trial of hospital versus home exercises. Fraenkel L, Bathon JM, England BR, et al. Concerning treatment, three recommendations were formulated; both exercise therapy and education on physiotherapy were recommended, whereas passive interventions (delivery of heat or cold, mechanical, electric and electromagnetic energy, massage, passive mobilization/manipulation and balneotherapy) were neither recommended nor discouraged. Based on evidence and expert opinion, recommendations were formulated. • The therapist has to involve the partner and other important people in the process because they have an important motivation-role. 1. N Engl J Med. Read more, © Physiopedia 2021 | Physiopedia is a registered charity in the UK, no. Prominent degenerative change is also seen at the ulnar-carpal articulation. The new EULAR guidelines on the management of rheumatoid arthritis (RA) were presented by Prof. Daniel Aletaha (Medical University Vienna, … Cytokine pathways and joint inflammation in rheumatoid arthritis. Review of the literature. The term idiopathic means that the exact cause of the condition is unknown, and medical professionals are … Found inside – Page 373Evidencebased guidelines for the secondary prevention offalls in older adults [with systematic review]. ... practice guidelines for electrotherapy and thermotherapy interventions in the management of rheumatoid arthritis in adults [with ... Epub 2012 Apr 11. Early and aggressive treatment with … All the currently available treatments are geared towards improving the symptoms and offering a better quality of life. Arthritis Rheum. The guideline includes 44 treatment recommendations, 7 of … Rheumatoid Arthritis: Diagnosis, Management and Monitoring Effective Date: September 30, 2012 Scope This guideline is intended to aid in early recognition, intervention and management of patients with rheumatoid arthritis (RA). People should also have rapid access to specialist care if their condition suddenly worsens. The American College of Rheumatology has updated its treatment guidelines for rheumatoid arthritis. 4: TEAR Trial for Early Aggressive RA and Future Treatment. For evaluating specific body structures and functions the handheld dynamometer, 6-minute walk test or Ästrand bicycle test (including Borg-scale for rating the perceived exertion), Escola Paulista de Medicina Range of Motion Scale and a Visual Analog Scale for pain and morning stiffness were recommended. Physical therapy (PT) can help people with rheumatoid arthritis (RA) by providing a personalized exercise program and simple movements to help them better manage the condition. Found inside – Page 58Unfortunately, the citation title that is specic to aquatic exercise for rheumatoid arthritis is a proto- col for a systematic ... “of over 24,000 randomised trials, systematic reviews, and clinical practice guidelines in physiotherapy. 8600 Rockville Pike Chronic phase -> minimum 4 repetitions for each joint in 2 to 3 days These exercises increase the mobility of the joint, but the concerned joint will not be loaded during this exercises. Found inside – Page E-208Bone mineral density in patients with rheumatoid arthritis:relation between disease severity and low bone ... British Society for Rheumatology and British Health Professionals in Rheumatology Guideline for the Management of rheumatoid ... Found inside – Page 157(b) What investigations can be used to confirm the diagnosis of rheumatoid arthritis? ... Non-surgical (hand therapy/physiotherapy): • Splinting (static and dynamic) • Active hand and wrist exercises • Household aids and personal aids ... Evidence based guidelines and current practice for physiotherapy management of knee osteoarthritis. The benefits of physical therapy interventions have been well documented. Other commonly affected joints include wrist, elbows, shoulders, hips, knees, ankles and metatarsophalangeal (MTP) joints. On examination, Rheumatoid arthritis can affect almost every organ in the body, RA has many effects on individuals including mortality, hospitalization, work disability, increase in medical cost/expenses, decreases of quality of life, and chronic pain. Start with a moderate-intensive exercise program. The last changes appeared in 2015. Progress to a high-intensive exercise program if possible aimed at improving aerobic capacity, strength and endurance. For severe systemic Sjögren’s, rituximab (Rituxan) is the first line of treatment and the only biologic recommended. 2: Oral and Subcutaneous Methotrexate Use for RA. Found inside – Page 255[Rehabilitation and outpatient physiotherapy in rheumatic disease patients. Results of cross-sectional studies of patients with rheumatoid arthritis or ankylosing spondylitis and rheumatologists]: Rehabilitative und ambulante ... Patient questionnaires, not joint counts, radiographic scores, or laboratory tests, provide the most significant predictors of severe 5-year outcomes in patients with RA, including functional status, work disability, costs, joint replacement surgery and premature death. INVESTIGATIONS 4 3.1 Laboratory Test 4 3.2 Imaging 5 3.2.1 Plain Radiography 5 3.2.2 Musculoskeletal Ultrasound 6 3.2.3 Magnetic Resonance Imaging 7 4. Adherence with treatment is an important factor which can influence the outcome of that treatment (Hayden et al., 2005).Adherent patients may have better treatment outcomes than non-adherent patients (Vermeire et al., 2001; WHO, 2003).Poor adherence to treatment has been identified across many healthcare disciplines including physiotherapy (Vasey, 1990; Friedrich et … The disease carries a significant burden of disability. 5. London, England: Royal College of Physicians; 2009. Physical therapists' management of rheumatoid arthritis: results of a Dutch survey. Stiffness in the joints in the morning may last up to several hours, usually greater than an hour. Is a long term high intensity exercise program effective and safe in patients with rheumatoid arthritis? (Level 1A), Brownfield A. Aromatherapy in arthritis: a study. 2012 Sep;10(3):142-8. doi: 10.1002/msc.1011. New priorities include minimizing/eliminating glucocorticoids; using methotrexate (MTX) as early first-line treatment and continuing it rather than rapidly … For people with RA, exercise can reduce pain, improve muscle function, and … Rheumatoid arthritis surgery may involve one or more of the following procedures: Synovectomy. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Found inside – Page 349Physical training in rheumatoid arthritis: a controlled long-term study. II. ... ACSM's resource manual for Guidelines for Exercise Testing and Prescription. 6th Edition. ... Physiotherapy 1996;82(3):168-173. Trost, SG, Owen, N, Bauman, ... Bethesda, MD 20894, Help • Formulate achievable goals with the patient. Acta Reumatol Port. Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Gabriel SE. Marry J. About 45% to 75% of patients with RA test positive for rheumatoid factor. In acute phase: isometric/static exercises -> be held for 6 seconds and repeated 5–10 times each day ; load = 40% 1RM. Physio - therapy is recommended in a number of multidis - ciplinary international3-7. Epub 2011 Jul 9. Avoiding food which causes inflammation like processed food, high salt, oils, butter, sugar, and animal products. Rheumatoid Arthritis: Developing Drug Products for Treatment. The treatment of patients with rheumatoid arthritis requries both pharmacological and non-pharmacological agents. Individuals with RA are 8 times more likely to have the functional disability compared with adults in the general population from the same community. Balance is key, schedule plenty of down time to reduce the likelihood of affected joints from becoming flared up, Educate family, staff at work, and other people who you interact with, they can help you during flare ups, Have a backup plan, be prepared in case of a flare up and become familiar with warning signs of a flare up. Epub 2016 Oct 5. The duration and intensity of the exercises should be based on the individual patient and their assessment, When the patient experiences an exacerbation and the joints are acutely inflamed then isometric exercises should be done, Revise the exercise program if pain persists 2 hours after the activity or there is an increase in joint swelling, Patients with active RA in their knees should avoid climbing stairs or weight lifting as it could lead to intra-articular pressure in the knee joint, Avoid excessive stress over the tendons with stretches and avoid ballistic movements. Primary care When patients present with joint symptoms suggestive of inflammatory arthritis, initial treatment by primary care should EP. Also, the therapist himself has to motivate the patient.• Keep in touch with the patient to be sure that the treatment was effective. Musculoskeletal Care. Physiopedia is not a substitute for professional advice or expert medical services from a qualified healthcare provider. The prevalence rate reported in 2002 ranged from 0.5% to 1% of the population and had regional variation. The International Classification of Functioning, Disability and Health (ICF) Core Sets for rheumatoid arthritis: a way to specify functioning. • Enough variation in the exercises is important to prevent boredom. eCollection 2017. (Level 1B), Bijlsma J.W.J., Geusens P.P.M.M., Kallenberg C.G.M., P.P. Careers. By Linda Rath. Reumatoïde artritis. For non-inflamed joints, active or active-assisted stretching of all major joints is essential to prevent contracture formation and maintain the current range of … For treatment evaluation at the level of activities and participation, the Health Assessment Questionnaire was recommended. Found inside – Page 763Stucki G , Kroeling P. Physical therapy and rehabilitation in the management of rheumatic disorders . ... Physical conditioning in children with arthritis : assessment and guidelines for exercise prescription . Arthritis Care Res 1994 ... 2007, 943-952. 2008;59;3:325-31. 2008 Oct;121(10 Suppl 1):S9-14. American College of Rheumatology Ad Hoc Committee on Clinical Guidelines. 2017 Dec 22;12(12):e0190211. NICE recommends specialist physiotherapy for people with rheumatoid arthritis. Significant predictors of functional decline among persons with RA are slow gait and a weak grip. Rheumatoid factor (antibody against the Fc portion of IgG). Rheumatoid arthritis (RA) is a common immune-mediated inflammatory arthritis, affecting approximately 5 per 1000 adults worldwide [].RA has a significant negative impact on daily activities, including work and household tasks, and is associated with high burden and impaired quality of life (QoL) [1, 2].During recent decades, the target of RA … And it’s important that your treatment plan starts with having specific treatment goals. 2008, Geri B. Neuberger et al., Predictors of exercise and effects of exercise on symptoms, function, aerobic fitness, and disease outcomes of rheumatoid arthritis. The main aim of the exercise program is increased hand function, which is suggested to be mediated by increases in strength, dexterity and range-of-movement. References . X-ray evidence of cartilage and bone destruction in addition to joint deformity and periarticular osteoporosis. Rheumatoid arthritis has no cure and is a progressive disease. Aletaha D, Neogi T, Silman AJ, et al. Mainly rheumatologists; patients and Is an oedematous thickened hyperplastic synovium infiltrated by lymphocytes T and B, plasmocytes, macrophages, and osteoclasts. USA: Tofacitinib, an oral Janus kinase inhibitor, is effective for the treatment of patients with polyarticular course juvenile idiopathic arthritis (JIA), show findings from a pivotal trial published in The Lancet. The use of magnetic fields in treatment of patients with rheumatoid arthritis. eCollection 2017 Jan-Dec. Hörnberg K, Sundström B, Innala L, Rantapää-Dahlqvist S, Wållberg-Jonsson S. PLoS One. Found inside – Page 547... fatigue, immobility, noncompliance to physio- or FACTORS occupational therapy guidelines, physical or emotional stress ... time of day (e.g. morning stiffness for more than 30 minutes is associated with rheumatoid arthritis), ... AU SO Arthritis Rheum. The nurse should inform the patient about the signs and symptoms of different organ systems and when to seek medical care. Rheumatoid arthritis (RA) is a chronic, erosive arthritis that requires early and aggressive treatment. Strategies that can help someone who is experiencing a flare up. Choy EH, Panayi GS. Would you like email updates of new search results? Unable to load your collection due to an error, Unable to load your delegates due to an error. The joints of the neck, back and pelvis become inflamed, causing pain and stiffness. Found inside – Page 602Treatment of rheumatoid arthritis: a global perspective on the use of antirheumatic drugs, Mod Rheumatol ... Ayling J, Marks R: Efficacy of paraffin wax baths for rheumatoid arthritic hands, Physiotherapy J 86(4):190–201, 2000. 28. 1: Rheumatoid Arthritis Treatment Guidelines. 2021 American College of Rheumatology guidelines for the treatment of rheumatoid arthritis. CLINICAL FEATURES 2 3. Hurkmans EJ, Jones A, Li LC, Vliet Vlieland TP. Conclusion: 5. h�bbd```b``y "CA$C�d��Ls���l�]";���O��y����]L��}`5�D����0 �� Increased prevalence of RA within families resulting from the interaction between patients genotype and environment. SINGH, Jasvinder A.; et al. Please enable it to take advantage of the complete set of features! It may be present in connective tissue disease, chronic infections, and healthy individuals, mostly in low titers. Pharmaceutical companies may deal in generic or brand medications and medical devices. (Level 1B), Ende CH Van den, Vliet Vlieland TP, Munneke M, Hazes JM. Treatment should be aimed at reaching a target of sustained remission or low disease activity in every patient. Patients with active disease should have frequent monitoring (every 1–3 months); if there is no improvement by at most 3 months after the start of treatment or the target has not been reached by 6 months, therapy should be adjusted.
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